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Choriocarcinoma
Choriocarcinoma is a malignant and aggressive cancer of the
placenta. It
is
characterized
by early
hematogenous
spread to
the lungs.
It belongs
to the far
end of the
spectrum of
gestational
trophoblastic
diseases (GTD).
Classification of GTDs
Broadly, GTDs can be classified in the following:
1. Hydatidiform Mole
a. Complete Mole
b. Partial Mole
2. Invasive Mole
3. Choriocarcinoma
4. Placental site trophoblastic tumor
Etiology/Epidemiology
It is preceded by:
* hydatidiform mole (50% of cases)
* Spontaneous abortion (20%of cases)
* ectopic pregnancy (2% of cases)
* normal term pregnancy (20-30% of cases)
Symptoms/Signs/Labs
* increased quantitative β-hCG levels
* vaginal bleeding
* shortness of breath
* hemoptysis (coughing up blood)
* chest pain
* chest X-ray shows multiple infiltrates of various
shapes in
both lungs
* presents in males as a testicular neoplasm
Pathology
On light microscopy, there is malignant trophoblastic
proliferation
without
hydropic
villi.
Treatment
Choriocarcinoma is one of the tumors that is most sensitive
to
chemotherapy.
The cure
rate, even
for
metastatic
choriocarcinoma,
is around
90-95%.
Virtually
everyone
without
metastases
can be cured
however
metastatic
disease to
the kidneys
and/or brain
is usually
fatal.
Chemotherapy
regimen
include
EMACO (etoposide,
methotrexate,
actinomycin
D,
cyclosphosphamide
and oncovin).
Hysterectomy (surgical removal of the uterus) can also be
offered to
patients >
40 years of
age or those
desiring
sterilization.
It may be
required for
those with
severe
infection
and
uncontrolled
bleeding.
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