Granulosa cell tumours, granulosa-theca, sex cord-stromal tumour group of ovarian neoplasms:: cancer symptom, definition syndrome acute, chronic, treatment, type cause sign history society, foundation information fact early cure picture disease diagnosis

Granulosa Cell Tumours

Granulosa cell tumours (or granulosa-theca) are part of the sex cord-stromal tumour group of ovarian neoplasms.

The peak age at which they occur is 50-55 years, but they may occur at any age.

Clinical presentation

Estrogens are produced by functioning tumours, and the clinical presentation depends on the patient's age.

* If the patient is postmenopausal, she usually presents with abnormal uterine bleeding.

* If the patient is of reproductive age, she would present with menometrorrhagia.

* If the patient has not undergone puberty, isosexual-pseudo-precocity may be seen.

Histology

The most characteristic gross appearance is a smooth surfaced solid and cystic lesion with the cysts filled with blood. Hemoperitoneum is an infrequent but classical presentation. A large variety of histological presentations exists, but they have two key features:

1. Call-Exner bodies (granulosa cells arranged haphazardly around a space containing eosinophilic fluid); and

2. Pale uniform nuclei, often with grooves.

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