Granulosa
cell tumour
Granulosa
cell tumours
(or
granulosa-theca)
are part of
the sex
cord-stromal
tumour group
of ovarian
neoplasms.
The peak age
at which
they occur
is 50-55
years, but
they may
occur at any
age.
Clinical
presentation
Estrogens
are produced
by
functioning
tumours, and
the clinical
presentation
depends on
the
patient's
age.
* If
the patient
is
postmenopausal,
she usually
presents
with
abnormal
uterine
bleeding.
* If the
patient is
of
reproductive
age, she
would
present with
menometrorrhagia.
* If the
patient has
not
undergone
puberty,
isosexual-pseudo-precocity
may be seen.
Histology
The most
characteristic
gross
appearance
is a smooth
surfaced
solid and
cystic
lesion with
the cysts
filled with
blood.
Hemoperitoneum
is an
infrequent
but
classical
presentation.
A large
variety of
histological
presentations
exists, but
they have
two key
features:
1. Call-Exner
bodies (granulosa
cells
arranged
haphazardly
around a
space
containing
eosinophilic
fluid); and
2. Pale
uniform
nuclei,
often with
grooves.
|